REDUCTION OF BREAST TUMOR BURDEN IN MICE BY A PRENYLATED FLAVONOID, ARTONIN E
نویسندگان
چکیده
منابع مشابه
Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
Artonin E is a prenylated flavonoid compound isolated from the stem bark of Artocarpus elasticus. This phytochemical has been previously reported to be drug-like with full compliance to Lipinski's rule of five and good physicochemical properties when compared with 95% of orally available drugs. It has also been shown to possess unique medicinal properties that can be utilized in view of allevia...
متن کاملPrenylated flavonoid morusin protects against TNBS-induced colitis in rats
Morusin is a prenylated flavonoid isolated from the root bark of Morus alba. Many studies have shown the ability of flavonoids to act as anti-inflammatory agents. The aim of this study was to evaluate the effect of morusin on experimentally colitis induced by 2,4,6-trinitrobenzensulfonic acid in Wistar rats and to compare it with sulfasalazine, a drug conventionally used in the treatment of inf...
متن کاملThe Role (S) of Vitamin E in Reduction of Fetal Malformation in Diabetic Mice
Purpose: Maternal type-1 diabetes during pregnancy causes an increased rate of malformation in fetuses.Many studies have demonstrated that an increase in the plasma level of free 02 radicals may increase the rate of abnormalities in the offspring of diabetic mothers. Because vitamin E is an active antioxidant, it may be able to decrease free 02 radicals and protect fetuses against congenital ma...
متن کاملArtonin E and Structural Analogs from Artocarpus Species Abrogates Estrogen Receptor Signaling in Breast Cancer.
The increasing rate of mortality ensued from breast cancer has encouraged research into safer and efficient therapy. The human Estrogen receptor α has been implicated in the majority of reported breast cancer cases. Molecular docking employing Glide, Schrodinger suite 2015, was used to study the binding affinities of small molecules from the Artocarpus species after their drug-like properties w...
متن کاملThe molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
Nature has provided us with a wide spectrum of disease healing phytochemicals like Artonin E, obtained from the root bark of Artocarpus elasticus. This molecule had been predicted to be drug-like, possessing unique medicinal properties. Despite strides made in chemotherapy, prognosis of the heterogenous aggressive triple negative breast cancer is still poor. This study was conducted to investig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Australasian Medical Journal
سال: 2017
ISSN: 1836-1935
DOI: 10.21767/amj.2017.3060